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This case study , published in 2023, describes three female patients taking semaglutide who visited their healthcare clinic due to severe mouth dryness, as well as minimal frothy saliva. After underlying medical problems were excluded (such as low water intake or a condition called Sjogrens disease) as the cause, the females were diagnosed with hyposalivation (dry mouth)

The Journal of Clinical Endocrinology & Metabolism 105, e2695e2709

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These findings suggest a class effect rather than a drug damaging follicles directly

These exploratory studies focus on mapping total caloric-balance modulation and how multi-receptor pathways support peak metabolic stability, providing expanded technical data on signaling behavior without any therapeutic or diagnostic applications